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Arthritis Rheum. 1993 Apr;36(4):460-4.

Cancer in systemic sclerosis.

Author information

1
University of Toronto, Rheumatic Disease Unit, Ontario, Canada.

Abstract

OBJECTIVE:

To determine whether the frequency of cancer is increased among patients with systemic sclerosis (SSc).

METHODS:

A retrospective chart review of 248 patients who were followed up prospectively was conducted.

RESULTS:

Cancers developed in 18 patients (7.3%) during 2,001 patient-years at risk. The most frequent types were cancers of the lung (7 patients) and breast (5 patients). Older age at diagnosis of SSc was a significant risk factor for cancer. Lung cancer was associated with the presence of pulmonary fibrosis. The age-standardized incidence rate for all cancers (7.9/1,000) was 2.1 times the overall rate in the Ontario population (P < 0.0001).

CONCLUSION:

The frequency of cancer is increased in patients with SSc.

PMID:
8457221
DOI:
10.1002/art.1780360405
[Indexed for MEDLINE]

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