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Science. 1993 Mar 26;259(5103):1915-7.

Activity-dependent regulation of conductances in model neurons.

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Department of Biology, Brandeis University, Waltham, MA 02254.


Neurons maintain their electrical activity patterns despite channel turnover, cell growth, and variable extracellular conditions. A model is presented in which maximal conductances of ionic currents depend on the intracellular concentration of calcium ions and so, indirectly, on activity. Model neurons with activity-dependent maximal conductances modify their conductances to maintain a given behavior when perturbed. Moreover, neurons that are described by identical sets of equations can develop different properties in response to different patterns of presynaptic activity.

[Indexed for MEDLINE]

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