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FEMS Microbiol Lett. 1993 Feb 1;106(3):309-14.

Immobilization of plasminogen on Escherichia coli flagella.

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Department of General Microbiology, University of Helsinki, Finland.


The interaction of plasminogen with flagella of Escherichia coli was investigated. Plasminogen bound to flagella purified from E. coli LE392, a commonly used cloning host, and E. coli IH3069, an O25H1 strain isolated from a case of newborn bacteremia. The binding was inhibited by the lysine analog epsilon-aminocaproic acid, suggesting involvement of the lysine-binding Kringle domains of plasminogen in the binding. Purified flagella enhanced the formation of plasmin activity in the presence of tissue-type plasminogen activator; a similar enhancement was observed with flagella-expressing LE392 cells.

[Indexed for MEDLINE]

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