Format

Send to

Choose Destination
Curr Opin Genet Dev. 1993 Feb;3(1):35-43.

Abl tyrosine kinase in signal transduction and cell-cycle regulation.

Author information

1
Department of Biology and Center for Molecular Genetics, University of California, San Diego 92093-0116.

Abstract

Although the biological function of the c-Abl tyrosine kinase remains unsolved, potentially productive avenues towards the elucidation of that function have been identified by recent progress. An F-actin binding and a sequence-specific DNA-binding domain have been discovered in c-Abl, and DNA binding has been shown to be cell-cycle regulated. Deletion of those two domains in the mouse c-Abl results in a loss of biological function despite the production of an active tyrosine kinase. These findings suggest a role for c-Abl in the regulation of processes occurring on F-actin and on specific DNA elements.

PMID:
8453272
DOI:
10.1016/s0959-437x(05)80338-7
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Elsevier Science
Loading ...
Support Center