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Curr Opin Immunol. 1993 Feb;5(1):108-13.

Glucocorticoids, lipocortins and the immune response.

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Department of Rheumatology, Medical College of St. Bartholomew's Hospital, London, UK.


Glucocorticoids are immunosuppressive and antiinflammatory agents that act through multiple mechanisms. This review highlights recent evidence that lipocortin-1, a member of the annexin family of calcium-binding proteins, can be induced by glucocorticoids, and may mediate some of the effects of glucocorticoids through putative lipocortin-1 receptors, which have been found on the surface of phagocytic cells. Recent advances in annexin biology have been drawn together to formulate a novel hypothesis for the regulation of inflammation.

[Indexed for MEDLINE]

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