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Biochemistry. 1993 Mar 2;32(8):2098-103.

A possible family of B-like triple helix structures: comparison with the Arnott A-like triple helix.

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Laboratoire CSSB, URA CNRS 1430, UFR Santé Médecine et Biologie Humaine, Université Paris XIII, Bobigny, France.


Recent experimental studies of the structure of triple helices show that their conformation in solution differs from the A-like structure derived from diffraction data on triple helix fibers by Arnott and co-workers. Here we show by means of molecular modeling that a family of triple helix structures may exist with similar conformational energies, but with a variety of sugar puckers. The characteristics of these putative triple helices are analyzed for three different base sequences: (T.AxT)n, (C.GxC+)n, and alternating (C.GxC+/T.AxT)n. In the case of (C.GxC+)n triple helix, infrared and Raman spectra have been obtained and clearly reveal the existence of both N- and S-type sugars in solution. The molecular mechanics calculations allow us to propose a stereochemically reasonable model for this triple helix, in good agreement with the vibrational spectroscopy results.

[Indexed for MEDLINE]

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