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Immunol Today. 1993 Feb;14(2):51-2.

Outsize peptides bulge out of the groove.

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  • 1Dept of Crystallography, Birkbeck College, London, UK.


The highly polymorphic MHC class I molecules are a central part of the cellular immune response to viruses. They present peptides, processed from viral proteins synthesized in the cytosol, to CD8+ cytotoxic T cells (CTL) that eliminate virus-infected cells. Here, Christopher Thorpe, describes the recent flurry of high resolution X-ray crystallographic structures that has allowed a general model of MHC-peptide interactions to be developed.

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