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Genitourin Med. 1993 Feb;69(1):29-30.

The testing of saliva samples for HIV-1 antibodies: reliability in a non-clinic setting.

Author information

1
Dulwich Hospital PHLS, London, UK.

Abstract

AIMS:

To assess the reliability of saliva samples as a means of testing for HIV-antibodies outside clinic settings.

METHODS:

Men taking part in a non-clinic longitudinal study of homosexually active men provided samples of saliva and blood. Sera were screened using a competitive ELISA (Wellcozyme) and positive sera were confirmed by an indirect ELISA (Abbott). Saliva samples were screened either using an IgG captive radioimmunoassay or an amplified ELISA.

RESULTS:

A total of 534 paired saliva and blood samples were tested. Overall sensitivity was 96.2% and specificity was 100%. None of the saliva tests were falsely positive for HIV-1 antibodies.

CONCLUSIONS:

HIV-1 saliva tests can reliably be used in a non-clinic or field setting. However, if results are to be given to respondents, it is necessary to offer adequate counselling and consider the mechanisms for referral and follow-up for those that are found to be HIV-1 antibody positive.

PMID:
8444477
PMCID:
PMC1195005
DOI:
10.1136/sti.69.1.29
[Indexed for MEDLINE]
Free PMC Article

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