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Immunol Today. 1993 Jan;14(1):15-7.

Towards a comprehensive view of immunoglobulin class switching.

Abstract

While it is well established that T cells play a prominent role in regulating Ig isotype switching in response to T-cell-dependent (TD) antigens, the events which control this process in response to antigens that do not recruit antigen-specific T cells (T-cell-independent (TI) antigens) is less clear. In this article, Clifford Snapper and James Mond suggest that the nature of the B-cell activator, in combination with cytokines produced by antigen non-specific cells, including macrophages, NK cells, and polyclonally activated B cells, may play an important role in the process leading to Ig isotype switching in response to TI antigens.

PMID:
8442856
DOI:
10.1016/0167-5699(93)90318-F
[Indexed for MEDLINE]

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