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Wien Klin Wochenschr. 1993;105(2):61-3.

[Mefloquine and sulfadoxine/pyrimethamine overdose in malaria tropica].

[Article in German]

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  • 1Abteilung für Infektionen und Chemotherapie, Innere Medizin I, Wien.


A 39 year-old man with malaria due to Plasmodium falciparum received 3500 mg mefloquine over 3 days, in addition to 3250 mg chloroquine and 175/3500 mg sulfadoxine/pyrimethamine. He developed severe neuropsychiatric symptoms and had to be hospitalized. Treatment with diazepam, haloperidol and thioridazine achieved relief of the severe symptoms after 4 days. The patient was still suffering from discrete neuropsychiatric symptoms 8 months after treatment.

[PubMed - indexed for MEDLINE]
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