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J Rheumatol. 1993 Jan;20(1):53-8.

IgA anti-dsDNA antibodies in systemic lupus erythematosus: occurrence, incidence and association with clinical and laboratory variables of disease activity.

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Department of Rheumatology, University Hospital Leiden, The Netherlands.


The relationship between IgA anti-dsDNA antibodies and systemic lupus erythematosus (SLE) disease activity was investigated. IgA anti-dsDNA antibodies were measured using ELISA techniques. Elevated serum levels of IgA anti-dsDNA antibodies were detected in 51% of the patients with SLE (n = 57) and 8% of the diseased controls (n = 214). The presence of IgA anti-dsDNA antibodies was associated with kidney and joint abnormalities, with hypocomplementemia and with circulating immune complexes. We conclude that increased levels of IgA anti-dsDNA antibodies are associated with disease activity in patients with SLE.

[Indexed for MEDLINE]

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