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J Pediatr. 1993 Mar;122(3):460-3.

Elevated 1,25-dihydroxyvitamin D serum concentrations in infants with subcutaneous fat necrosis.

Author information

1
Department of Pediatrics, University of L├╝beck, Bremen-Nord, Federal Republic of Germany.

Abstract

Two infants with subcutaneous fat necrosis had hypercalcemia that normalized during glucocorticoid treatment. The combination of hypercalcemia, normal concentration of 25-hydroxyvitamin D, an elevated concentration of 1,25-dihydroxyvitamin D, a suppressed parathyroid hormone level, and low-normal bone turnover indicated abnormal 1,25-dihydroxyvitamin D production with increased intestinal absorption of calcium. Unregulated production of 1,25-dihydroxyvitamin D by the granulomatous cells of fat necrosis may cause hypercalcemia.

PMID:
8441106
DOI:
10.1016/s0022-3476(05)83441-9
[Indexed for MEDLINE]

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