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Ann Pharmacother. 1993 Feb;27(2):180-1.

Labetalol: response and safety in critically ill hemorrhagic stroke patients.

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1
Department of Pharmacy Services, Henry Ford Hospital, Detroit, MI 48202.

Abstract

OBJECTIVE:

To observe and characterize the blood pressure (BP)-lowering and adverse hemodynamic and/or central nervous system effects of intravenous bolus doses of labetalol in hemorrhagic stroke patients.

DESIGN:

Observational, prospective, pilot survey conducted over an eight-week period.

SETTING:

Surgical intensive care unit.

PARTICIPANTS:

Patients admitted with an intracerebral or subarachnoid hemorrhage.

MAIN OUTCOME PARAMETERS:

Absolute decline in systolic BP (SBP) and diastolic BP (DBP), time to peak reduction in SBP and DBP, and adverse hemodynamic and mental status changes.

RESULTS:

Labetalol at doses between 5 and 25 mg lowered SBP by 6-19 percent (baseline 152-184 mm Hg) and DBP by 3-26 percent (baseline 50-99 mm Hg). Adverse hemodynamic or mental status changes were not detected following labetalol administration.

CONCLUSIONS:

Small (< or = 25 mg) intravenous bolus doses of labetalol produce mild decreases in BP in hemorrhagic stroke patients.

PMID:
8439694
[Indexed for MEDLINE]
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