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Transplant Proc. 1993 Feb;25(1 Pt 1):262-4.

Effect of anti-HLA antibodies on the long-term survival of heart and kidney allografts.

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Department of Surgery, College of Physicians & Surgeons, Columbia University, New York, New York 10032.


Study of anti-HLA antibodies in a population of 238 primary renal and 199 primary heart allograft recipients showed significant association between development of anti-HLA antibodies and that of chronic allograft rejection. The 5-year renal allograft survival was 70% in recipients without antibodies and 53% in recipients who developed anti-HLA alloantibodies during the first year following transplantation. Heart allograft survival at 5 years was 91% in patients without and 78% in patients with antibodies during the first 12 months posttransplantation. Development of antibodies is associated with acute rejection episodes and probably with the release of soluble HLA antigens.

[Indexed for MEDLINE]

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