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Trends Genet. 1993 Jan;9(1):22-6.

The search for the familial breast/ovarian cancer gene.

Author information

1
Somatic Cell Genetics Laboratory, ICRF, London, UK.

Abstract

Familial breast cancer is a very common autosomal dominant disorder in women. A predisposing gene for breast and ovarian cancer (BRCA1) has been mapped by linkage analysis to the long arm of chromosome 17. In almost all families with breast and ovarian cancer and half of those with only breast cancer, the disease is linked to this gene. The BRCA1 gene, which is also believed to be involved in sporadic breast and ovarian cancer, should soon be identified.

PMID:
8434413
DOI:
10.1016/0168-9525(93)90068-S
[Indexed for MEDLINE]

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