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Arthritis Rheum. 1993 Feb;36(2):199-203.

Temporal covariation of soluble interleukin-2 receptor levels, daily stress, and disease activity in rheumatoid arthritis.

Author information

1
Department of Psychiatry, University of Connecticut School of Medicine, Farmington.

Abstract

OBJECTIVE:

To examine synchronous changes in soluble interleukin-2 receptor (sIL-2R) levels, daily indicators of emotional stress, joint inflammation, and reported pain in patients with rheumatoid arthritis (RA).

METHODS:

Fourteen patients were studied on each of 6 occasions, 2 weeks apart. Measures included daily ratings of mood disturbance, undesirable events, and joint pain; clinical examination of joint swelling; and serum assays of sIL-2R. Pooled within-person correlations among these variables were calculated.

RESULTS:

Consistent with the results of previous research, joint inflammation covaried directly with sIL-2R levels. Changes in mood disturbance were unrelated to changes in joint inflammation, but increases in mood disturbance were linked with decreases in sIL-2R levels and increases in reported joint pain.

CONCLUSION:

These findings provide preliminary evidence that psychoimmune processes may be implicated in short-term changes in RA disease activity.

PMID:
8431208
DOI:
10.1002/art.1780360209
[Indexed for MEDLINE]

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