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Plast Reconstr Surg. 1993 Feb;91(2):213-6.

Mitotic activity in expanded human skin.

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Department of Plastic and Reconstructive Surgery, Karolinska Hospital, Stockholm, Sweden.


In 20 patients subjected to breast reconstruction by means of tissue expansion, a skin biopsy was obtained at the vertex of the breast before and the day after expansion. Samples were incubated in [3H]thymidine, and the number of labeled cells were counted. A statistically significant rise in the number of labeled basal and suprabasal keratinocytes was seen after expansion. The findings suggest a net gain of tissue not only by stretching but also by formation of new tissue generated by tissue expansion.

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