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Br J Cancer. 1993 Jan;67(1):7-9.

Epidermal growth factor receptor in breast cancer. Comparison with non malignant breast tissue.

Author information

1
Center for the Study of Biological Markers of Malignancy, Regional General Hospital, Venice, Italy.

Abstract

Epidermal growth factor receptors were measured using a radioligand binding assay in membrane preparations from 67 cancer and 25 non-malignant tissues. The binding characteristics of EGFr were similar in tumour and normal breast membranes. The concentrations were significantly higher in non-malignant tissue than in cancer. EGFr concentrations were directly correlated with steroid receptors in non-malignant tissue, whereas in cancer an inverse correlation between EGFr and steroid receptors was found.

PMID:
8427782
PMCID:
PMC1968236
DOI:
10.1038/bjc.1993.2
[Indexed for MEDLINE]
Free PMC Article

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