Format

Send to

Choose Destination
See comment in PubMed Commons below
Am J Clin Nutr. 1993 Feb;57(2 Suppl):236S-239S.

Selenium deficiency, thyroid hormone metabolism, and thyroid hormone deiodinases.

Author information

1
Division of Biochemical Sciences, Rowett Research Institute, Aberdeen, Scotland.

Abstract

Much research into the functions of selenium in the cell has concentrated on its role in selenium-containing glutathione peroxidases. However, selenium was recently shown to be an essential component of type I iodothyronine 5'-deiodinase in rats, which converts thyroxin to the more biologically active hormone 3,5,3'-triiodothyronine. Thus, selenium-deficient rats have low tissue deiodinase activities and abnormal thyroid hormone metabolism. The discovery of this function for selenium in thyroid hormone metabolism has important implications for the interpretation of the effects of selenium deficiency, especially in individuals with an adequate vitamin E status.

PMID:
8427195
[Indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for HighWire
    Loading ...
    Support Center