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J Am Geriatr Soc. 1993 Feb;41(2):149-52.

Effects of testosterone replacement therapy in old hypogonadal males: a preliminary study.

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Division of Geriatric Medicine, St. Louis University Medical School, MO 63104.



To examine the effects of testosterone administration to older hypogonadal males (bioavailable testosterone less than 70 ng/dL).


Alternate-case controlled trial.


St. Louis University.


Eight males (mean age 77.6 +/- 2.3 years) who received testosterone and six males (mean age 76 +/- 2.3 years) who served as controls. Selected from alumni of the SHEP trial and attendees at the St. Louis University Impotence Clinic.


Testosterone enanthate (200 mg/mL) was administered intramuscularly to the treatment group every 2 weeks for 3 months.


Serum testosterone, bioavailable testosterone and estradiol, weight, % body fat, right hand muscle strength, balance, cholesterol, HDL-cholesterol, hematocrit, BUN, creatinine, albumin, calcium, PTH, 25(OH) vitamin D, 1,25(OH)2 vitamin D, osteocalcin, prostate-specific antigen, and fructosamine.


Males who received testosterone had a significant increase in testosterone and bioavailable testosterone concentration, hematocrit, right hand muscle strength and osteocalcin concentration. They had a decrease in cholesterol (without a change in HDL-cholesterol) levels and decreased BUN/Creatinine ratios.


These preliminary findings support the need for long term studies of testosterone therapy in older hypogonadal males.

[Indexed for MEDLINE]

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