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Fertil Steril. 1993 Feb;59(2):339-42.

Comparison of intracervical, intrauterine, and intratubal techniques for donor insemination.

Author information

1
Department of Obstetrics and Gynecology, University of Michigan Medical Center, Ann Arbor 48109-0718.

Abstract

OBJECTIVE:

To compare the efficacy of intracervical insemination (ICI), intrauterine insemination (IUI), and a combination of intratubal and intrauterine insemination (ITI/IUI) for donor insemination.

DESIGN:

Prospective randomized clinical trial.

SETTING:

The University of Michigan donor insemination program.

PATIENTS, PARTICIPANTS:

Forty-one women undergoing donor insemination with cryopreserved sperm for either isolated male factor or male factor plus ovulatory dysfunction corrected by clomiphene citrate.

INTERVENTION:

Each patient was randomly assigned to receive each of the three insemination techniques in consecutive cycles until pregnancy occurred or the patient dropped from the study.

MAIN OUTCOME MEASURES:

Cycle fecundity rates were compared using the chi 2 test, and cumulative pregnancy rates (PRs) determined by life table analysis were compared using a log-rank test.

RESULTS:

Cycle fecundity rate was significantly higher for IUI (18.3%) than for ICI (3.9%) or ITI/IUI (7.3%). By life table analysis, the cumulative PR for IUI was significantly higher than for ICI, but the PR for ITI/IUI was not.

CONCLUSION:

For donor insemination with cryopreserved sperm, IUI increases cycle fecundity compared with ICI. The addition of ITI to IUI, however, interferes with the apparent beneficial effect of IUI alone.

PMID:
8425628
[Indexed for MEDLINE]
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