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FEBS Lett. 1993 Jan 11;315(3):318-22.

The rat delta-1 and delta-2 subunits extend the excitatory amino acid receptor family.

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Laboratory of Molecular Neuroscience, Center for Molecular Biology (ZMBH), Heidelberg University, Germany.


We have characterized a second member (delta-2) of a new class of subunits for the ligand-gated excitatory amino acid receptor superfamily. The sequence of delta-2 exhibits an average identity of 25% and 18.5% to the non-NMDA and NMDA receptor subunits, respectively. The rat delta-2 gene is expressed predominantly in Purkinje cells of the cerebellum whereas only low levels of delta-1 transcripts are found in the adult brain. However, delta-1 gene expression undergoes a pronounced developmental peak, with particularly high mRNA levels in the caudate putamen of late embryonic/early postnatal stages.

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