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Epilepsia. 1993 Jan-Feb;34(1):161-2.

Clarithromycin-carbamazepine interaction: a case report.

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1
Laboratory of Neuropharmacology, University of Bologna, Italy.

Abstract

We report a clinically relevant interaction between a new macrolide antibiotic, clarithromycin, and carbamazepine (CBZ). In a patient receiving CBZ monotherapy, 10-day antibiotic treatment increased CBZ concentration despite concomitant CBZ dose reduction and doubled the CBZ concentration/dose ratio. Concentration of the CBZ epoxide (CBZ-E) metabolite was reduced, suggesting that the interaction occurs at a metabolic level.

PMID:
8422851
[Indexed for MEDLINE]

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