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Cancer. 1993 Jan 15;71(2):297-301.

The association of Helicobacter pylori with gastric cancer and preneoplastic gastric lesions in Chiapas, Mexico.

Author information

1
Instituto Nacional de Cancerología, Tlalpan, Mexico.

Abstract

BACKGROUND:

Helicobacter pylori recently was identified as a risk factor for gastric cancer. Its association with preneoplastic conditions of the stomach, however, is undocumented.

METHODS:

Gastric biopsy specimens from 245 symptomatic patients were examined for neoplastic and preneoplastic lesions and for gastric H. pylori infection. The sera of 183 subjects were tested by enzyme-linked immunosorbent assay (ELISA) for anti-H. pylori immunoglobulin G.

RESULTS:

Histologic H. pylori infection, usually accompanied by acute and chronic gastritis, was found in 85.7% of patients. There was a strong association between H. pylori in the tissue and atrophy (relative risk, 15.0; 95% confidence interval, 4.2-56.6), intestinal metaplasia (relative risk, 5.7; 95% confidence interval, 1.9-16.8), and dysplasia or cancer (relative risk, 4.0; 95% confidence interval, 1.1-14.8). The ELISA was 93.2% sensitive and 57.1% specific for histologic infection with a positive predictive value of 96.1%. The overall seroprevalence rate was 86.1%, with no significant difference in rates between patients with cancer precursors and those with normal stomachs.

CONCLUSIONS:

In this high-risk population, precursor lesions for adenocarcinoma were associated universally with H. pylori infection.

PMID:
8422620
[Indexed for MEDLINE]

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