Send to

Choose Destination
Nature. 1993 Jan 7;361(6407):31-9.

A synaptic model of memory: long-term potentiation in the hippocampus.

Author information

Division of Neurophysiology and Neuropharmacology, National Institute of Medical Research, Mill Hill, London, UK.


Long-term potentiation of synaptic transmission in the hippocampus is the primary experimental model for investigating the synaptic basis of learning and memory in vertebrates. The best understood form of long-term potentiation is induced by the activation of the N-methyl-D-aspartate receptor complex. This subtype of glutamate receptor endows long-term potentiation with Hebbian characteristics, and allows electrical events at the postsynaptic membrane to be transduced into chemical signals which, in turn, are thought to activate both pre- and postsynaptic mechanisms to generate a persistent increase in synaptic strength.

[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Nature Publishing Group
Loading ...
Support Center