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J Neurochem. 1993 Jan;60(1):1-9.

Agonist regulation of gene expression of adrenergic receptors and G proteins.

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Department of Molecular Pharmacology, School of Medicine, SUNY/Stony Brook 11794-8651.


Study of transmembrane signaling via G proteins has focused to a large extent upon investigations of individual G protein-linked receptor-effector systems. Agonist-induced desensitization and down-regulation of beta-adrenergic receptors, for example, have been studied extensively and adopted as a general model for G protein-linked receptor regulation. This review focuses not only on agonist regulation of adrenergic receptor gene expression, but also on how agonists regulate opposing adrenergic receptor-mediated pathways. This important feature of G protein-mediated pathways, i.e., cross-regulation and integration of information among several pathways, will be discussed in the context of what has been learned in the adrenergic receptor-coupled pathways.

[Indexed for MEDLINE]

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