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Am J Med Sci. 1993 Jan;305(1):36-9.

Case report: acyclovir neurotoxicity and nephrotoxicity--the role for hemodialysis.

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1
Wishard Memorial Hospital, Indiana University School of Medicine, Indianapolis.

Abstract

Severe neurotoxicity and acute renal failure developed in a patient with newly diagnosed AIDS while receiving high-dosage intravenous acyclovir for disseminated herpes zoster. Hemodialysis resulted in a rapid resolution of neurologic symptoms and was associated with a reduction in plasma acyclovir concentration. Acute hemodialysis therapy should be considered in cases of serious neurotoxicity secondary to acyclovir, especially when accompanied by renal failure.

PMID:
8416680
[Indexed for MEDLINE]

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