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Med Res Rev. 1993 Jan;13(1):105-23.

Growth factor second messenger systems: oncogenes and the heterotrimeric GTP-binding protein connection.

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Division of Neuroscience, John Curtin School of Medical Research, Australian National University, Canberra.


We feel that there is now compelling evidence that the GTP-binding proteins play more than just a coordinating role in the actions of both tyrosine kinase and nontyrosine kinase receptor signal transduction. These similarities appear to represent just a small component of the convergence in the signaling pathways for structurally dissimilar receptor subsets. Future years will see further understanding of the intricacies of these G-protein-proto-oncogene interactions, and the extension into the potential role in growth factor action played by the expanding number of known members of this G-protein family.

[Indexed for MEDLINE]

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