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Ophthalmology. 1993 Oct;100(10):1580-4.

An association between hypothyroidism and primary open-angle glaucoma.

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1
Department of Ophthalmology, McGill University, Montreal, Canada.

Abstract

PURPOSE:

To test the hypothesis that there is an association between hypothyroidism and primary open-angle glaucoma.

METHODS:

The study was conducted in a case-control fashion. Sixty-four patients with primary open-angle glaucoma were evaluated for hypothyroidism by history and by undergoing a thyroid-stimulating hormone immunoradiometric assay. Sixty-four control subjects from the general eye clinic were evaluated in the same manner. Patients found to have elevated thyroid-stimulating hormone immunoradiometric assay were evaluated by an endocrinologist for hypothyroidism.

RESULTS:

Of the primary open-angle glaucoma group, 23.4% had hypothyroidism. A diagnosis was made previously in 12.5% patients, and 10.9% were newly diagnosed. Of the control subjects, 4.7% had hypothyroidism. A diagnosis had been made previously in 1.6% of the control subjects, and 3.1% were newly diagnosed. The difference between the two groups was found to be statistically significant.

CONCLUSION:

A statistically significant association between hypothyroidism and primary open-angle glaucoma is demonstrated. There is a large group (10.9%) of patients with primary open-angle glaucoma with undiagnosed hypothyroidism.

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PMID:
8414419
[Indexed for MEDLINE]
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