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Nature. 1993 Oct 21;365(6448):721-7.

Direct observation of kinesin stepping by optical trapping interferometry.

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1
Rowland Institute for Science, Cambridge, Massachusetts 02142.

Abstract

Do biological motors move with regular steps? To address this question, we constructed instrumentation with the spatial and temporal sensitivity to resolve movement on a molecular scale. We deposited silica beads carrying single molecules of the motor protein kinesin on microtubules using optical tweezers and analysed their motion under controlled loads by interferometry. We find that kinesin moves with 8-nm steps.

PMID:
8413650
DOI:
10.1038/365721a0
[Indexed for MEDLINE]

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