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Matrix. 1993 Jul;13(4):297-306.

Type A modules: interacting domains found in several non-fibrillar collagens and in other extracellular matrix proteins.

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Divisione di Oncologia Sperimentale 2, Centro di Riferimento Oncologico, Aviano, Italy.


A 200-amino acid long motif first recognized in von Willebrand Factor (type A module) has been found in components of the extracellular matrix, hemostasis, cellular adhesion, and immune defense mechanisms. At present the extracellular matrix is the predominant site of expression of type A modules since at least four non-fibrillar collagens and two non-collagenous proteins contain a variable number of modules ranging from one to twelve. The modules conform to a consensus motif made of short conserved subregions separated by stretches of variable length. The proteins that incorporate type A modules participate in numerous biological events such as cell adhesion, migration, homing, pattern formation, and signal transduction after interaction with a large array of ligands.

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