Format

Send to

Choose Destination
See comment in PubMed Commons below
J Pathol. 1993 Aug;170(4):435-40.

Monoclonal antibodies to cytoskeletal proteins: an immunohistochemical investigation of human colon cancer.

Author information

1
Department of Surgery, University of Dundee, Ninewells Hospital and Medical School, U.K.

Abstract

Monoclonal antibodies raised to a number of microfilament-associated proteins were shown to recognize the appropriate proteins in extracts from human colon tissue. They were then used in an immunohistochemical study of normal colonic mucosa, adenomas, and adenocarcinomas. A strong reaction was seen in stromal cells within the tumours (both adenomas and adenocarcinomas) when frozen sections were stained with antibodies to filamin and caldesmon. In addition, a similar reaction was seen in the adenocarcinomas when stained with antibodies to talin and gelsolin. We believe that immunohistochemical staining with these antibodies reveals a tumour-induced process in the surrounding cells, possibly related to a host response to tumours.

PMID:
8410492
DOI:
10.1002/path.1711700406
[Indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Wiley
    Loading ...
    Support Center