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Biochem Mol Biol Int. 1993 Jul;30(4):697-704.

Ornithine decarboxylase inactivation by putrescine: involvement of lipid peroxidation.

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1
Laboratory of Environmental Carcinogenesis, Industrial Toxicology Research Center, M. G. Marg, Lucknow, India.

Abstract

Effect of polyamines on 12-O-tetradecanoyl phorbol-13-acetate (TPA)-induced reduction of lipid peroxidation was studied. Putrescine protected this lowering of lipid peroxidation in a concentration-dependent manner, but spermidine or spermine could not do so. Putrescine also inhibited the TPA-induced ornithine decarboxylase (ODC) activity and lowered the free sulfhydryl content of TPA exposed mouse skin. These observations indicate that putrescine inactivates ODC probably by lowering SH groups through lipid peroxidation.

PMID:
8401327
[Indexed for MEDLINE]
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