Abstract
The photolysis of rabbit red blood cells induced by several photosensitizers has been studied. Membrane photohemolysis was found to be dependent on light dose (J/cm2) for hematoporphyrin (HP), methylene blue (MB) and toluidine blue (TB). No significant hemolysis was detected when mesotetra (4N-methylpyridyl) porphine (T4MPyP) plus light was used. Sodium azide inhibited, whereas deuterium oxide potentiated membrane lysis with HP, MB and TB. In the case of T4MPyP no differences were observed when using sodium azide or deuterium oxide.
Publication types
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Comparative Study
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Cell Membrane / drug effects
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Cell Membrane / radiation effects
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Erythrocytes / drug effects*
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Erythrocytes / radiation effects*
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Hematoporphyrins / pharmacology
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Hemoglobins / drug effects
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Hemoglobins / metabolism
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Hemolysis
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Light
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Mesoporphyrins / pharmacology
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Methylene Blue / pharmacology
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Photolysis*
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Photosensitizing Agents / pharmacology*
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Porphyrins / pharmacology
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Rabbits
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Tolonium Chloride / pharmacology
Substances
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Hematoporphyrins
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Hemoglobins
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Mesoporphyrins
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Photosensitizing Agents
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Porphyrins
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Tolonium Chloride
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tetra(4-N-methylpyridyl)porphine
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Methylene Blue