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Immunol Today. 1993 Aug;14(8):412-5.

Cyclic re-entry of germinal center B cells and the efficiency of affinity maturation.

Author information

1
Santa Fe Institute, NM 87501.

Abstract

Affinity maturation of the humoral immune response by somatic hypermutation is marked by a rapid and dramatic increase in affinity for the eliciting antigen. We suggest that the optimal mutation schedule is one in which periods of rapid mutation alternate with periods of mutation-free growth. The multicompartmental structure of the germinal center, together with re-entry of positively selected B cells back into the germinal center, will naturally implement such a schedule, thereby providing an anatomical basis for the efficiency of the germinal center reaction.

PMID:
8397781
DOI:
10.1016/0167-5699(93)90145-B
[Indexed for MEDLINE]

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