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Immunol Today. 1993 Aug;14(8):405-11.

Discriminating intrinsic and antigen-selected mutational hotspots in immunoglobulin V genes.

Author information

1
Medical Research Council Laboratory of Molecular Biology, Addenbrookes Hospital, Cambridge, UK.

Abstract

Studies of the antibody hypermutation mechanism have revealed that it is not a random process but exhibits characteristic nucleotide substitution preferences. Here, Alexander Betz and colleagues show that these innate nucleotide substitution preferences can be used to examine databases of antigen-selected V gene sequences and thereby distinguish intrinsic from antigen-selected hotspots. This analysis reveals intrinsic mutational hotspots in both VH and VL genes, reflecting innate features of the hypermutation machinery which may give clues to the enzymatic mechanism.

PMID:
8397780
DOI:
10.1016/0167-5699(93)90144-a
[Indexed for MEDLINE]

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