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Immunol Today. 1993 Aug;14(8):400-4.

The maturation of the immune response.

Erratum in

  • Immunol Today 1993 Oct;14(10):479.

Abstract

In a T-cell dependent immune response, the repertoire of antigen-activated B cells is diversified by a hypermutation mechanism. Only high-affinity variants are selected into the pool of memory cells. This maturation process takes place in a special micro-environment, the germinal centre. Here, Claudia Berek and Mike Ziegner discuss the mechanisms underlying these processes.

PMID:
8397779
DOI:
10.1016/0167-5699(93)90143-9
[Indexed for MEDLINE]

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