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Immunol Today. 1993 Jun;14(6):310-6.

Cancer vaccines.

Author information

1
Department of Oncology, Johns Hopkins University School of Medicine, Baltimore, MD 21205.

Erratum in

  • Immunol Today. 2008 Apr;29(4):149.

Abstract

1993 represents the 100th anniversary of William Coley's first report of tumor regressions induced by immune system activation in response to bacterial toxins. While many subsequent cancer vaccine trials have yielded tantalizing results, active immunotherapy has not yet become an established modality of cancer therapy. Newer molecular vaccine approaches based on rational immunological principles have resulted in improved systemic antitumor effects in animal models. Ultimately the genetic definition of tumor-specific antigens will allow the development of targeted antigen-specific vaccines for cancer therapy.

PMID:
8397772
DOI:
10.1016/0167-5699(93)90051-L
[Indexed for MEDLINE]

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