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Neuropsychopharmacology. 1993 Aug;9(1):83-91.

Schizophrenia: a neurodevelopmental perspective.

Author information

1
Genetics Section, Institute of Psychiatry, Denmark Hill, London.

Abstract

The role of aberrant neurodevelopment in the etiology of schizophrenia is reviewed in light of recent neuropathologic, neurochemical, and neuroimaging evidence of cerebral abnormalities in schizophrenic patients. There may exist some genetic defect in the control of brain development. Clinical epidemiologic surveys highlight the importance of obstetric complications, and prenatal exposure to influenza epidemics in contributing to these abnormalities. It is suggested that such environmental hazards and aberrations in the control of early brain development produce the neuronal phenotype that manifests as schizophrenia with early age of onset of symptoms associated with soft neurologic signs and is more common in young males.

PMID:
8397727
DOI:
10.1038/npp.1993.46
[Indexed for MEDLINE]
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