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Eur J Pharmacol. 1993 Jul 15;246(2):149-55.

Cloning and functional expression of a human parathyroid hormone receptor.

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  • 1Sandoz Pharma Ltd, Preclinical Research, Basel, Switzerland.


We have cloned a human receptor for parathyroid hormone from a kidney complementary DNA library. The deduced sequence of 593 amino acids shows high homology to the previously cloned receptors from opossum and rat. Expressed in COS-1 cells, the human receptor binds to parathyroid hormone-(1-38) with high affinity (pKD = 8.5) and is functionally coupled to adenylate cyclase (pEC50 = 9.4). At high concentrations of agonist, the receptor also activates phosphoinositide turnover.

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