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Virology. 1993 Oct;196(2):888-91.

The octamer binding protein Oct-2 inhibits transactivation of the herpes simplex virus immediate-early genes by the virion protein Vmw65.

Author information

1
Division of Molecular Pathology, University College London Medical School, United Kingdom.

Abstract

Transactivation by a complex of the cellular transcription factor Oct-1 and the virion protein Vmw65 is necessary for the high-level activity of the HSV immediate-early promoters during lytic infection. We show that this trans-activation can be inhibited by two forms of the Oct-2 transcription factor which are expressed at high levels in neuronal cells as well as by the isolated DNA binding, POU domain of Oct-2. The inhibition of Oct-1-Vmw65 DNA binding by these neuronal forms of Oct-2 is likely to play a critical role in the nonpermissivity of neuronal cells for the HSV lytic cycle and therefore in the establishment of latent infections.

PMID:
8396817
DOI:
10.1006/viro.1993.1552
[Indexed for MEDLINE]

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