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FEBS Lett. 1993 Aug 23;329(1-2):227-31.

Defective association of dystrophin with sarcolemmal glycoproteins in the cardiomyopathic hamster heart.

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1
Department of Molecular Physiology, National Cardiovascular Center Research Institute, Osaka, Japan.

Abstract

In ventricular muscle from 30- to 60-day-old Bio 14.6 cardiomyopathic hamsters, dystrophin-associated glycoproteins of 43, 50 and 150 kDa are markedly reduced in abundance. In particular, the 50-kDa glycoprotein is totally deficient in the sarcolemma of myopathic ventricular myocytes as revealed by immunofluorescence microscopy. The dystrophin-glycoprotein complex formation is defective in the cardiomyopathic hamster heart, because dystrophin and the glycoproteins behave independently when digitonin-solubilized ventricular homogenates are fractionated on wheat germ agglutinin beads or anti-dystrophin immunoaffinity beads.

PMID:
8394832
DOI:
10.1016/0014-5793(93)80227-l
[Indexed for MEDLINE]
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