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Acta Neuropathol. 1993;85(6):679-81.

Progression of myopathology in Kearns-Sayre syndrome: a morphological follow-up study.

Author information

1
Department of Neurology, University of W├╝rzburg, Germany.

Abstract

We report on the progression of myopathology by comparing two biopsies from a patient with a Kearns-Sayre-Syndrome. The first biopsy was taken in 1979 and showed 10% ragged-red fibers. Myopathic changes were slight including internal nuclei and fiber splitting in 10% of the fibers. Electron microscopy revealed typical mitochondrial abnormalities with regard to number and shape. In 1989 a second biopsy was performed for an extended analysis of mitochondrial DNA. This time less than 5% of all fibers were ragged-red. Severe myopathic changes could be detected which so far has rarely been reported in mitochondrial cytopathy.

PMID:
8393264
DOI:
10.1007/bf00334681
[Indexed for MEDLINE]

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