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J Pediatr. 1993 Jul;123(1):96-8.

Enhanced urinary excretion of leukotriene E4 in patients with mevalonate kinase deficiency.

Author information

1
University Children's Hospital, Heidelberg, Germany.

Abstract

In patients with mevalonate kinase deficiency, urinary excretion of the leukotriene LTE4 was found to be elevated. A positive linear relationship between increased urinary excretion of mevalonate and LTE4 (n = 5) suggests that increased cysteinyl leukotriene synthesis is involved in the pathomechanisms of this disease.

PMID:
8391572
DOI:
10.1016/s0022-3476(05)81548-3
[Indexed for MEDLINE]

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