Send to

Choose Destination
Neuroreport. 1993 May;4(5):591-4.

Priming of homosynaptic long-term depression in hippocampus by previous synaptic activity.

Author information

Department of Neuroscience, Albert Einstein College of Medicine, Bronx, New York 10461.


Mechanisms regulating long-lasting, activity-dependent decreases in synaptic strength are poorly understood. Theoretical studies have suggested that the critical level (threshold) of synaptic activity needed to induce long-term depression (LTD) versus potentiation (LTP) of synaptic transmission should vary as a function of previous synaptic activity. In order to determine whether such a 'sliding threshold' is indeed a physiological phenomenon, we stimulated Schaffer collateral afferents in area CA1 of rat hippocampal slices at frequencies from 1 to 5 Hz before or after inducing LTP.

[Indexed for MEDLINE]

Supplemental Content

Loading ...
Support Center