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J Gen Virol. 1993 Jun;74 ( Pt 6):1103-13.

Expression, identification and subcellular localization of the proteins encoded by the hepatitis C viral genome.

Author information

1
Chiron Corporation, Emeryville, California 94608.

Abstract

We have expressed the full-length coding region and selected domains of the hepatitis C virus (HCV) cDNA in mammalian cells by transfection. Using HCV antibody-positive human sera and monospecific antibodies the proteins encoded by the putative structural and non-structural regions of the open reading frame of HCV were identified as core (p22), E1 (gp32-35), E2 (gp68-72), NS2 (p23), NS3 (p72), NS4a and b (p10 and p27) and NS5a and b (p56 and p70). We have also defined the subcellular localizations of the HCV proteins using indirect immunofluorescence assays.

PMID:
8389800
DOI:
10.1099/0022-1317-74-6-1103
[Indexed for MEDLINE]

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