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FEBS Lett. 1993 Jun 14;324(2):140-2.

Recombinant GABAA receptor function and ethanol.

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Institute of Pharmacology, University of Bern, Switzerland.


Different combinations of cloned subunits of the rat brain GABAA receptor were expressed in Xenopus oocytes. Possible effects of ethanol on the expressed GABA-induced chloride current were determined. The consequence of replacing the gamma 2S subunit by the alternatively spliced variant gamma 2L was specifically tested on the responsiveness to ethanol. A significant stimulation of the GABA response was only observed at very high concentrations (> 60 mM) of ethanol. No differential response was observed between subunit combinations containing different gamma 2 subunit splice variants.

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