Format

Send to

Choose Destination
Trends Biochem Sci. 1993 Apr;18(4):128-31.

The MAP kinase cascade is essential for diverse signal transduction pathways.

Author information

1
Department of Biophysics, Faculty of Science, University of Tokyo, Japan.

Abstract

Mitogen-activated protein (MAP) kinases are activated by combined tyrosine and threonine phosphorylation catalysed by MAP kinase kinase, a novel class of protein kinases with dual specificity for both tyrosine and serine/threonine. MAP kinase kinase is turned on by serine/threonine phosphorylation catalysed by an immediate upstream kinase. The MAP kinase cascade appears to be conserved during evolution and thus might play an essential role in diverse intracellular signaling processes from yeasts to vertebrates.

PMID:
8388132
DOI:
10.1016/0968-0004(93)90019-j
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Elsevier Science
Loading ...
Support Center