Format

Send to

Choose Destination
Arthritis Rheum. 1993 May;36(5):685-90.

Cold-induced potentiation of alpha 2-adrenergic vasoconstriction in primary Raynaud's disease.

Author information

1
Department of Psychiatry, Wayne State University School of Medicine, Detroit, Michigan.

Abstract

OBJECTIVE:

To determine the effects of local cooling on alpha-adrenergic responses in the fingers of patients with idiopathic Raynaud's disease.

METHODS:

Clonidine HCl and phenylephrine HCl were administered through a brachial artery catheter while blood flow was measured by plethysmography in cooled and uncooled fingers.

RESULTS:

Cooling potentiated alpha 2-adrenergic vasoconstriction in the patients but depressed this response in the controls. Vasoconstrictive responses to phenylephrine were not significantly affected by cooling but were significantly greater in the patients than in the controls.

CONCLUSION:

Cold-induced sensitization of peripheral vascular alpha 2-adrenoceptors may be involved in the mechanism by which cooling triggers the vasospastic attacks of Raynaud's disease.

PMID:
8387786
DOI:
10.1002/art.1780360517
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Wiley
Loading ...
Support Center