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Proc Natl Acad Sci U S A. 1993 Mar 15;90(6):2375-9.

Disruption of the transthyretin gene results in mice with depressed levels of plasma retinol and thyroid hormone.

Author information

1
Department of Genetics & Development, Columbia University College of Physicians & Surgeons, New York, NY 10032.

Abstract

Transthyretin (TTR) is thought to play a major role in vitamin A metabolism and thyroid hormone transport in mammals. To investigate the physiological role of the TTR protein in development of the embryo and in the adult, we used gene targeting techniques to generate a null mutation at the mouse ttr locus. The resultant mutant animals are phenotypically normal, viable, and fertile. However, levels of serum retinol, retinol-binding protein, and thyroid hormone are significantly depressed in the mutant animals. These observations demonstrate that the TTR protein maintains normal levels of these metabolites in the circulating plasma.

PMID:
8384721
PMCID:
PMC46089
[Indexed for MEDLINE]
Free PMC Article

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